Building Wisdom With BDNF—and Ketamine

Psychology Today | 03.04.2026 06:51
Over the past several decades, we’ve learned more about neuroplasticity, which is the intrinsic property of the brain that allows it to adapt and reorganize itself. Neuroplasticity allows an aging brain to make the adaptive changes needed to maintain cognitive functioning and resilience. One particular brain protein, BDNF, plays an important role in neuroplasticity—and boosting it can help improve our brain’s health and stave off cognitive decline. Anyone can do that by making some changes to their daily habits, but there’s another way to increase BDNF: ketamine.